The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where the selenite alone was non-toxic. Sodium selenite was found to enhance the fluorescence emission of Hpd and augment the Hpd-sensitized photooxidation of tryptophan. The data indicate that sodium selenite is able to disaggregate Hpd, thereby enhancing Hpd-sensitized phototoxicity.
Benjamin H. S. Lau
A. Graham Maxwell
Elwood S. McCluskey
Robert W. Teel
Master of Arts (MA)
Year Degree Awarded
Date (Title Page)
Library of Congress/MESH Subject Headings
Neoplasms -- therapy; Photochemotherapy; Cytotoxins; Selenium
Loma Linda University Libraries
This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.
Tosk, Jeffrey M., "Selenium-induced Enhancement of Hematoporphyrin Derivative Phototoxicity in Murine Bladder Tumor Cells" (1986). Loma Linda University Electronic Theses, Dissertations & Projects. 744.
Loma Linda University Electronic Theses and Dissertations
Loma Linda University. Del E. Webb Memorial Library. University Archives