Evolution of the stroke paradigm: A review of delayed recanalization

Authors

Richard Camara, Loma Linda University
Nathanael Matei, Loma Linda University
John H. Zhang, Loma Linda UniversityFollow

Document Type

Article

Publication Date

5-1-2021

Publication Title

Journal of Cerebral Blood Flow and Metabolism

ISSN

0271678X

E-ISSN

15597016

Abstract

While the time window for reperfusion after ischemic stroke continues to increase, many patients are not candidates for reperfusion under current guidelines that allow for reperfusion within 24 h after last known well time; however, many case studies report favorable outcomes beyond 24 h after symptom onset for both spontaneous and medically induced recanalization. Furthermore, modern imaging allows for identification of penumbra at extended time points, and reperfusion risk factors and complications are becoming better understood. Taken together, continued urgency exists to better understand the pathophysiologic mechanisms and ideal setting of delayed recanalization beyond 24 h after onset of ischemia.

Volume

41

Issue

5

First Page

945

Last Page

957

DOI

10.1177/0271678X20978861

PubMed ID

33325765

Recommended Citation

Camara, Richard; Matei, Nathanael; and Zhang, John H., "Evolution of the stroke paradigm: A review of delayed recanalization" (2021). Loma Linda University Faculty Publications. 278.
https://scholarsrepository.llu.edu/fac_pubs/278