Laboratory model to evaluate efficacy of an experimental titanium oxide nanofibers bleaching agent

Authors

Clayton Tran, Division of General Dentistry, Loma Linda University School of Dentistry, Loma Linda, California, USA.Follow
Ellin Choi, Division of General Dentistry, Loma Linda University School of Dentistry, Loma Linda, California, USA.Follow
Brittany Watu, Division of General Dentistry, Loma Linda University School of Dentistry, Loma Linda, California, USA.Follow
Udochukwu Oyoyo, Division of General Dentistry, Loma Linda University School of Dentistry, Loma Linda, California, USA.Follow
Christopher Perry, Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, California, USA.Follow
So Ran Kwon, Division of General Dentistry, Loma Linda University School of Dentistry, Loma Linda, California, USA.Follow

Document Type

Article

Publication Date

11-1-2021

Publication Title

Restorative dentistry & endodontics

ISSN

2234-7658

Abstract

Objectives: This study aimed to use a laboratory model to evaluate the efficacy of an experimental bleaching agent. Materials and Methods: The model used human extracted molars that were treated and measured for bleaching efficacy. Teeth ( = 50) were distributed into 5 groups: Negative control (NC): immersion in water for 8 hours; Nanofibers (NFs): Experimental titanium dioxide nanofibers with stirring and light activation for 8 hours; Whitestrips (WS): Crest 3D White Glamorous White Whitestrips, 2 applications daily for 30 minutes, 14 days; 1% hydrogen peroxide (HP) standard: 1% hydrogen peroxide for 8 hours; and 30% HP standard: 30% hydrogen peroxide for 8 hours. Instrumental measurements were performed using a spectrophotometer. Results were recorded at baseline, 1-day post-bleaching, and 1-week post-bleaching. Kruskal-Wallis procedure was used to determine differences in color change. Pearson correlation was used to evaluate the relationship between visual and instrumental measurements. Tests of hypotheses were 2-sided with alpha = 0.05. Results: There was no significant difference in color parameters (L1, a1, b1, and shade guide units [SGU]) at baseline ( > 0.05). There was a significant difference among the groups for overall color change (ΔE*ab) and change in shade guide units (ΔSGU) at 1-day and 1-week post-bleaching ( < 0.05). The higher the HP concentration, the higher the color change as expressed in ΔSGU and ΔE*ab. The negative control exceeded the perceptibility threshold of ΔE* = 1.2 regardless of time point. NFs showed a decrease in chroma, but were not statistically different compared to the negative control. Conclusions: The laboratory model was successful in screening an experimental bleaching agent.

Volume

46

Issue

4

First Page

e47

DOI

10.5395/rde.2021.46.e47

PubMed ID

34909411

Recommended Citation

Tran, Clayton; Choi, Ellin; Watu, Brittany; Oyoyo, Udochukwu; Perry, Christopher; and Kwon, So Ran, "Laboratory model to evaluate efficacy of an experimental titanium oxide nanofibers bleaching agent" (2021). Loma Linda University Faculty Publications. 315.
https://scholarsrepository.llu.edu/fac_pubs/315