The roles of astrocyte in the brain pathologies following ischemic stroke

Authors

Linlin Sun, Department of Anatomy and Histology, School of Basic Medical Sciences , Peking University , Beijing , China.
Yixuan Zhang, Department of Anatomy and Histology, School of Basic Medical Sciences , Peking University , Beijing , China.
E Liu, Department of Anatomy and Histology, School of Basic Medical Sciences , Peking University , Beijing , China.
Qingyi Ma, Center for Perinatal Biology, School of Medicine , Loma Linda University , Loma Linda , USA.Follow
Manaenko Anatol, Departments of Neurology , University of Erlangen-Nuremberg , Erlangen , Germany.
Hongbin Han, Beijing Key Lab of Magnetic Resonance Imaging Technology , Beijing , China.
Junhao Yan, Department of Anatomy and Histology, School of Basic Medical Sciences , Peking University , Beijing , China.

Document Type

Article

Publication Date

1-1-2019

Publication Title

Brain injury

E-ISSN

1362-301X

Abstract

: In this work, we systematically explored the physiological functions of astrocytes and their roles following ischemic stroke, additionally, the potential therapy strategy targeting the astrocytes was also discussed. : This work searched the PubMed database (including MEDLINE) until 14 Feb 2018, and furthermore, the studies were identified through cross-referencing and by consulting the experts in this field. : This study indicated that the astrocytes can not only play harmful roles following ischemic stroke through release of inflammatory factors and formation of glial scar but also have protective effects through quenching glutamate excitotoxicity and maintaining the clearance function of glymphatic system in brain. : Owing to their important roles in physiological functions of brain and in the pathological conditions following ischemic stroke, the astrocytes might be a potential but promising therapeutic target for treating the ischemic stroke in the future.

Volume

33

Issue

6

First Page

712

Last Page

716

DOI

10.1080/02699052.2018.1531311

PubMed ID

30335519

Recommended Citation

Sun, Linlin; Zhang, Yixuan; Liu, E; Ma, Qingyi; Anatol, Manaenko; Han, Hongbin; and Yan, Junhao, "The roles of astrocyte in the brain pathologies following ischemic stroke" (2019). Loma Linda University Faculty Publications. 331.
https://scholarsrepository.llu.edu/fac_pubs/331