Effects of Cariogenic and Noncariogenic Diets on the Concentration of the Parotid Hormone Releasing Factor in Rat Hypothalami

Author

Melva Joan Brown

Abstract

Hypothalamic and cortical extracts from various cariogenically grouped rats which had been maintained on either a Purina diet or a high sucrose diet (HSD) for three months were infused intravenously into 28 days old rats to determine if there was a titer of parotid hormone releasing factor (PRF) capable of facilitating fluid movement (FM) in the teeth. The hypothalamic and cortical extracts obtained from Purina-fed rats with 0-caries and the hypothalamic extracts from BSD-fed rats conclusively demonstrated FM stimulatory ability. Other Purina-fed groups were essentially biologically ineffective, however, extracts from HSD-fed caries groups including scores 11-40 demonstrated extremely potent FM stimulating ability. The extract from the 1-10 caries group for the HSD-fed rats was an effective stimulator but only one-third as potent as the physiologically homeostatic 0-caries group. Extracts from groups containing more than 40 caries did not demonstrate stimulatory ability at the tested doses, suggesting that synthesis of PRF is not adversely affected within an optimal range when caries develop.

LLU Discipline

Physiology

Department

Physiology

School

Graduate School

First Advisor

John Leonora

Second Advisor

Kenneth A. Arendt

Third Advisor

Raymond G. Hall

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

1976

Date (Title Page)

6-1976

Language

English

Library of Congress/MESH Subject Headings

Diet, Cariogenic; Dental Caries -- diet therapy

Type

Thesis

Page Count

vi; 29

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Copyright

Author

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Recommended Citation

Brown, Melva Joan, "Effects of Cariogenic and Noncariogenic Diets on the Concentration of the Parotid Hormone Releasing Factor in Rat Hypothalami" (1976). Loma Linda University Electronic Theses, Dissertations & Projects. 2275.
https://scholarsrepository.llu.edu/etd/2275

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives