Abstract

Aim: The aim of this study was to evaluate any possible beneficial effects of omega-3 polyunsaturated fatty acids (Ω-3 PUFAs) as a dietary supplement when incorporated into the diet of rats that had periodontitis induced via a ligature model.

Materials and Methods: 20 male rats (Sprague Dawley) were divided into 2 groups as following: 1) Control group with ligature-induced periodontitis and no Ω-3 PUFA in the diet; and 2) Test group with ligature-induced periodontitis and Ω-3 PUFA introduced in the diet. The ligature was placed around the mandibular first molars in the gingiva sulcus for a period of 15 days on both groups. The control group was given regular chow with no supplementation in their diet. However, the test group was provided with a custom fed diet of Ω-3 PUFA chow given every day for a period of 15 days. Both groups of animals were euthanized at day 15, and jaws containing the first molar, epithelial tissue, and alveolar bone crest were subjected to histologic analyses.

Results: The usage of Ω-3 PUFA in this animal-model study showed no statistically significant lower rate of alveolar bone loss (P<0.05) when compared to animals fed a regular chow. However, the effects of Ω-3 PUFA are evident in the reduction of alveolar bone loss in the test group when compared to the control group. The data were analyzed with the independent sample t-test.

Discussion: These findings reveal that diets incorporated with an Ω-3 PUFA diet can possibly decrease the amount of alveolar bone loss in a ligature induced periodontitis induced animal model. However, more studies are needed with a larger animal sample size.

LLU Discipline

Periodontics

Department

Periodontics

School

School of Dentistry

First Advisor

Yoon Jeong Kim

Second Advisor

Dwight Rice

Third Advisor

Udochukwu Oyoyo

Degree Name

Master of Science (MS)

Degree Level

M.S.

Year Degree Awarded

2021

Date (Title Page)

12-2021

Language

English

Library of Congress/MESH Subject Headings

Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Alveolar Bone Loss; Diet; Periodontitis

Type

Thesis

Page Count

x, 19 p.

Digital Format

PDF

Digital Publisher

Loma Linda University Libraries

Usage Rights

This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Collection

Loma Linda University Electronic Theses and Dissertations

Collection Website

http://scholarsrepository.llu.edu/etd/

Repository

Loma Linda University. Del E. Webb Memorial Library. University Archives

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