Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury

Authors

Amandine Jullienne, Loma Linda UniversityFollow
Arjang Salehi, Loma Linda UniversityFollow
Bethann M. Affeldt, Loma Linda UniversityFollow
Mohsen Baghchechi, Loma Linda UniversityFollow
Elizabeth Haddad, Loma Linda UniversityFollow
Angela Avitua, Loma Linda UniversityFollow
Mark Walsworth, Loma Linda UniversityFollow
Isabelle Enhalric, Loma Linda UniversityFollow
Mary Hamer, Loma Linda UniversityFollow
Sonali Bhakta, Loma Linda UniversityFollow
Jiping Tang, Loma Linda UniversityFollow
John Zhang, Loma Linda UniversityFollow
William Pearce, Loma Linda UniversityFollow
Andrea Obenaus, University of California–IrvineFollow

Abstract

Traumatic brain injuries (TBI) occur in 1.7 million people each year in the USA. Little is known about how the cerebrovasculature is altered after TBI. We previously reported that TBI elicits acute decrements in cerebral vessels near the injury site in rats followed by revascularization over the subsequent 2 weeks. Sexual dimorphism of the brain is well documented and different hormonal levels in males and females differentially modify the recovery process after injury. However, the effects of biological sex on the temporal evolution of revascularization following TBI are understudied. Using a model of controlled cortical impact in male and female mice, we set out to determine if the injury and the repair process are affected by sex.

Recommended Citation

Jullienne, Amandine; Salehi, Arjang; Affeldt, Bethann M.; Baghchechi, Mohsen; Haddad, Elizabeth; Avitua, Angela; Walsworth, Mark; Enhalric, Isabelle; Hamer, Mary; Bhakta, Sonali; Tang, Jiping; Zhang, John; Pearce, William; and Obenaus, Andrea (2018) "Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury," Loma Linda University Student Journal: Vol. 3: Iss. 1, Article 13.
Available at: https://scholarsrepository.llu.edu/llu-student-journal/vol3/iss1/13